Description
RNASE2, is a non-secretory ribonuclease that belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein is found in eosinophil granulocytes and closely related to the eosinophil cationic protein (RNASE3) from which it diverged 50 million years ago after the split between the old world and the new world monkeys. It is relatively neutral and has cytotoxic properties. It may generate host defense via roles in promoting leukocyte activation, maturation, and chemotaxis. It has also been studied in the context of defense against pathogen infection in mammals. Recombinant human RNASE2, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques